DIRECT - Innovative Medicines Initiative:
DIabetes REsearCh on patient straTification

Prediabetes Glycaemic Deterioration (2.1)

We know that some people are at a higher risk of developing diabetes than other people. We know some of the reasons why this is so. For example, risk is increased if people are overweight or if they have a family history of diabetes. However, there is still a lot we don’t know about why people get diabetes. We want to identify biomarkers that will help us find out which patient’s blood sugar levels will get worse over time and which patient’s blood sugar levels will remain the same. This will help us develop the best ways to stop and treat diabetes.


Studying people who are more likely to get diabetes, (in the “pre-diabetes” stage), may give us new information on how diabetes develops. It will also help us to work out the people who are likely to get the disease and those who will not. What is important to remember is that many people with pre-diabetes remain at this stage for a long time and some will never get the disease.


For more information take a look at the Patient Information Sheets provided to participants before they join the study:

Information from previous studies contributing to the DIRECT project:


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