DIRECT - Innovative Medicines Initiative:
DIabetes REsearCh on patient straTification

Metformin intolerance study (3.2)

On the Patient Information Leaflet provided with Metformin it says that gastrointestinal problems such as nausea, vomiting, diarrhoea, stomach pain or loss of appetite are very common side effects of metformin (affecting more than 1 in 10 people). These side effects are more marked for some people than for others


We are trying to understand why some patients with diabetes develop severe gut related side effects to metformin, whereas other people can take it in high doses without any side effects at all. We believe that studying people who have had severe gut related side effects to metformin in the past will help to give us a clearer understanding of why some people develop side effects and others don’t.


For more information take a look at the Patient Information Sheets provided to participants before they join the study:

Information from previous studies contributing to the DIRECT project:


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