DIRECT - Innovative Medicines Initiative:
DIabetes REsearCh on patient straTification

Work Package 5 (WP5):
Data repository and integrative biology

The overall aim of WP5 is to perform and develop methods for integrative, functional analysis of human variation data which go beyond what can be achieved by each of the groups involved in the DIRECT Consortium. Furthermore, the data generated in the project will be combined with other proprietary and publicly available data sources.


Additionally, it is a major aim of WP5 to develop - across all consortium partners – a secure data warehouse infrastructure needed to collect data input, perform computational data analysis, including phenotype definition and systems level analyses that is compliant with all ethical, legal and regulatory requirements. The data warehouse structure will be compatible with the integrative pathway oriented systems biology methodology.


Data from WPs 2 to 4 will target multiple phenotypes, and the variable amounts of genomic and non-genomic data will provide numerous opportunities for performing integrative analysis of core data sets across multiple levels. The overlapping biology of phenotypes and shared levels of data across the cohorts will be optimal for an integrated biology approach.



Participants
  • Sanofi-Aventis Deutschland GmbH
  • University of Dundee
  • Technical University of Denmark
  • Université de Genève
  • The Chancellor, Masters and Scholars of the University of Oxford
  • Novo Nordisk A/S